173x Filetype PPTX File size 1.97 MB Source: meskc.ac.in
• Paulin Hogeweg(1979) – • Bio-biology,Informatique-Data processing • Study of information content and flow in a biological system with the help of IT. • Multidisciplinary branch • Historical background: • 1961-identified mRNA- Jacob,Meselson,Francois Jacob • 1977-DNA Sequencing-Sanger,Gilbert • 1983-Release of GEN Bank • 1983-Sequence database sequence algorithm • 1985 Similarity searching—FASTP&FASTN • 1988 NCBI By NIH/NLM • 1990-BLAST-Pairwise sequence similarity search • 1991-Expressed sequence tag sequencing • 1994 EMBL • 1995 First bacterial genome analysed • 1996 Yeast genome analysed • 2000-Pseudomonas genome ,A.thaliana genome • 2001-Human Genome • 2005-Rice Genome sequenced. BIOLOGICAL DATABASES • Database is a System to store,search and retrieve any type of data • Biological database-Information of DNA,RNA,Proteins,3D images,Organism specific informations. • PRIMARY,SECONDARY &DERIVATIVE DATABASES • PRIMARY DATABASES:Information of Nucleic acid,Protein,and their structure. Original submission by experimentalists and controlled by original submitter. Eg:Gen Bank,SWISS PROT,PDB SECONDARY DATABASES: With additional information from analysis of primary databases.TrEMBL,PROSITE DERIVATIVE DATABASES/COMPOSITE DATABASES:From primary databases.controlled by third party.Eg.NCBI,RefSeq,UniGene.
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