186x Filetype PDF File size 1.63 MB Source: old.amu.ac.in
Microencapsulation TECHNIQUES TO MANUFACTURE MICROCAPSULES Physical method • Pan coating • Air-suspension coating • Centrifugal extrusion • Spray drying Physico-chemical methods • Coacervation-phase separation Chemical methods • Polymerization • Interfacial polymerization • In situ polymerization PAN COATING The pan coating process, widely used in the pharmaceutical industry, is among the oldest industrial procedures for forming small, coated particles or tablets. The method involves the application of a coating composition to a moving bed of particles with the concurrent use of heated air to facilitate evaporation of the solvent. The particles are tumbled in a pan or other device while the coating material is applied slowly. Suitable for relatively large particles, greater than 600 microns in size.
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