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picture1_Powerpoint Online Course Free 67071 | 4 2018 04 08!08 31 25 Pm


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File: Powerpoint Online Course Free 67071 | 4 2018 04 08!08 31 25 Pm
the central paradigm of clinical pharmacology the dose concentration effect relationship efficacy dose concentration pharmacokinetics toxicity pharmacodynamic introduction pharmacokinetics describes the time course of a drug in a body fluid ...

icon picture PPTX Filetype Power Point PPTX | Posted on 28 Aug 2022 | 3 years ago
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  The central paradigm of clinical pharmacology: The 
      dose-concentration-effect relationship
                                 Efficacy
        Dose     concentration
        pharmacokinetics        Toxicity
                      Pharmacodynamic
  Introduction 
  • Pharmacokinetics describes the time course of 
   a drug in a body fluid, preferably plasma or 
   blood, that results from the administration of 
   a certain dosage regimen.
  • It comprises all processes affecting drug 
   absorption, distribution, metabolism, and 
   excretion. 
  • Simplified, pharmacokinetics characterizes 
   what the body does to the drug.
  •  In contrast, pharmacodynamic  characterizes 
   the intensity of a drug effect or toxicity 
   resulting from certain drug  concentration in a 
   body fluid, usually at the assumed site of drug 
   action. It can be simplified to what the drug 
   does to the body 
                          Protein bound drug                      Tissue bound drug
     Drug Absorption                                Distribution
                                                                                             s
                          Plasma concentration                    Tissue concentration       c
                                                                                             t
                                                                                             e
                                                                                             n
                                                                                             i
                                                                                             k
                        Elimination                                                          o
                                                                                             c
                                                                                             a
                                                                                             m
                                                                                             r
                                                                                             a
                                                                          Drug bound         h
                                 Metabolism            Drug in effect         to             P
                                    Excretion         compartment          Receptor/ 
                                                                            effector
                                                                                             s
                                                                                             c
                                                                                             i
                                                                 Post-receptor               m
                                                                    events                   a
                                                                                             n
                                                                                             y
                                      biochemical                                            d
                                                                                             o
                                        events                                               c
                                                                                             a
            Pharmacological                                                                  m
                                                                                             r
               response                                                                      a
                                                                                             h
                                                                                             P
  • General pharmacokinetic and pharmacodynamic 
   principles are to a large extent equally applicable to 
   protein and peptide drugs as they are to traditional 
   small molecule-based therapeutics.
  • Deviations from some of these principles and additional 
   challenges with regard to the characterization of the 
   pharmacokinetics and pharmacodynamics of peptide 
   and protein therapeutics, however, arise from some of 
   their specific properties: 
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...The central paradigm of clinical pharmacology dose concentration effect relationship efficacy pharmacokinetics toxicity pharmacodynamic introduction describes time course a drug in body fluid preferably plasma or blood that results from administration certain dosage regimen it comprises all processes affecting absorption distribution metabolism and excretion simplified characterizes what does to contrast intensity resulting usually at assumed site action can be protein bound tissue s c t e n i k elimination o m r h p compartment receptor effector post events y biochemical d pharmacological response general pharmacokinetic principles are large extent equally applicable peptide drugs as they traditional small molecule based therapeutics deviations some these additional challenges with regard characterization pharmacodynamics however arise their specific properties...

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