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Powders as a primary requirement for Powders as a primary requirement for pharmaceutical dosage form. pharmaceutical dosage form. INTRODUCTION • Definition: Preformulatoin study is defined as investigation of physical and Chemical properties of a drug and mixture of drug and excipient. • Goal of preformulation: The major goal of preformulatoin is to gather data, Which will permit the rational development of safe and efficacious dosage form.. • Preformulation also helps in formulating new dosage form of already existing drug. PREFORMULATION • DRUG DISCOVERY Formulation BRIDGE &Development • In short , by preformulation one can determine the best suitable dosage form for the drug molecule. HYGROSCOPICITY:- CONTENTS :- A. INTRODUCTION B. METHOD OF DETERMINATION C. IMPORTANCE OF MEASUREMENT D. METHOD OF IMPROVEMENT (A)INTRODUCTION : Hygroscopicity: - It is the tendency of material to absorb moisture from atmosphere & get dynamic equilibrium with water in the atmosphere. Deliquescent: - It is the hygroscopic substance which absorb moisture from air and they can be liquefied by partially or wholly forming solution. Efflorescent: - a substance which loses water to form a lower hydrate or become anhydrous is termed as efflorescent. (B) METHOD OF DETERMINATION : • To carry out study, sample of compound are accurately weighed into container and placed at various humid condition for period of upto 2 weeks. If Weight gain – Deliquescent or Hygroscopic If Weight loss – Efflorescent • Also determined by TGA, GC, & KF titration • Versaperm has deviced a WVTR meter that can measure the permeability of package to moisture.so that humidity can be accurately controlled.
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