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picture1_Pro Sanjay Khattri  Anti Rheumatoid Drugs


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File: Pro Sanjay Khattri Anti Rheumatoid Drugs
antirheumatoid drugs prof sanjay khattri dept of pharmacology therapeutics king george s medical university 1 rheumatoid arthritis ra rheumatoid arthritis ra is a chronic inflammatory disease of unknown aetiology marked ...

icon picture PDF Filetype PDF | Posted on 17 Jan 2023 | 2 years ago
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        ANTIRHEUMATOID DRUGS
   Prof. Sanjay Khattri
   Dept. of Pharmacology & Therapeutics
   King George’s Medical University                   1
             RHEUMATOID ARTHRITIS (RA)
   •  Rheumatoid arthritis (RA) is a chronic inflammatory disease of 
      unknown aetiology marked by a symmetric, peripheral 
      polyarthritis.
   •  The wrists, metacarpophalangeal(MCP), and proximal 
      interphalangeal(PIP) joints stand out as the most frequently 
      involved joints.
   •  RA may result in a variety of extraarticular manifestations,
      including fatigue, subcutaneous nodules, lung involvement, 
      pericarditis, peripheral neuropathy, vasculitis and hematologic 
      abnormalities.
                                                                          2
             RHEUMATOID ARTHRITIS (RA)
   •  The pathogenic mechanisms of synovial inflammation result from 
      a complex interplay of genetic, environmental and immunologic 
      factors that produces dysregulation of the immune system and a 
      breakdown in self-tolerance.
   •  RA is associated with allelic variation in the HLA-DRB 1 gene,
      which encodes the MHC IIβ - chain molecule.
   •  In RA preclinical stage is characterized by a breakdown in self-
      tolerance, supported by the finding that autoantibodies RF and 
      anti-CCP (cyclic citrullinated peptide) antibodies may be found in 
      sera.
   •  The pathologic hallmarks of RA are synovial inflammation and 
      proliferation, focal bone erosions and thinning of articular 
      cartilage.
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...Antirheumatoid drugs prof sanjay khattri dept of pharmacology therapeutics king george s medical university rheumatoid arthritis ra is a chronic inflammatory disease unknown aetiology marked by symmetric peripheral polyarthritis the wrists metacarpophalangeal mcp and proximal interphalangeal pip joints stand out as most frequently involved may result in variety extraarticular manifestations including fatigue subcutaneous nodules lung involvement pericarditis neuropathy vasculitis hematologic abnormalities pathogenic mechanisms synovial inflammation from complex interplay genetic environmental immunologic factors that produces dysregulation immune system breakdown self tolerance associated with allelic variation hla drb gene which encodes mhc ii chain molecule preclinical stage characterized supported finding autoantibodies rf anti ccp cyclic citrullinated peptide antibodies be found sera pathologic hallmarks are proliferation focal bone erosions thinning articular cartilage...

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