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uttley et al bmc psychiatry 2015 15 151 doi 10 1186 s12888 015 0528 4 research article open access the clinical and cost effectiveness of group art therapy for people ...

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         Uttley et al. BMC Psychiatry  (2015) 15:151 
         DOI 10.1186/s12888-015-0528-4
          RESEARCH ARTICLE                                            Open Access
         The clinical and cost effectiveness of group
         art therapy for people with non-psychotic
         mental health disorders: a systematic
         review and cost-effectiveness analysis
                 *
         Lesley Uttley , Matt Stevenson, Alison Scope, Andrew Rawdin and Anthea Sutton
          Abstract
          Background: The majority of mental health problems are non-psychotic (e.g., depression, anxiety, and phobias). For
          some people, art therapy may be a more acceptable alternative form of psychological therapy than standard forms
          of treatment, such as talking therapies. This study was part of a health technology assessment commissioned by
          the National Institute for Health Research, UK and aimed to systematically appraise the clinical and cost-effective
          evidence for art therapy for people with non-psychotic mental health disorders.
          Methods: Comprehensive literature searches for studies examining art therapy in populations with non-psychotic
          mental health disorders were performed in May 2013. A quantitative systematic review of clinical effectiveness and
          a systematic review of studies evaluating the cost-effectiveness of group art therapy were conducted.
          Results: Eleven randomised controlled trials were included (533 patients). Meta-analysis was not possible due to
          clinical heterogeneity and insufficient comparable data on outcome measures across studies. The control groups
          varied between studies but included: no treatment/wait-list, attention placebo controls and psychological therapy
          comparators. Art therapy was associated with significant positive changes relative to the control group in mental
          health symptoms in 7 of the 11 studies. A de novo model was constructed and populated with data identified from
          the clinical review. Scenario analyses were conducted allowing comparisons of group art therapy with wait-list
          control and group art therapy with group verbal therapy. Group art-therapy appeared cost-effective compared with
          wait-list control with high certainty although generalisability to the target population was unclear; group verbal
          therapy appeared more cost-effective than art therapy but there was considerable uncertainty and a sizeable
          probability that art therapy was more cost effective.
          Conclusions: From the limited available evidence art therapy was associated with positive effects compared with
          control in a number of studies in patients with different clinical profiles. The included trials were generally of poor
          quality and are therefore likely to be at high risk of bias. Art therapy appeared to be cost-effective versus wait-list
          but further studies are needed to confirm this finding in the target population. There was insufficient evidence to
          make an informed comparison of the cost-effectiveness of group art therapy with group verbal therapy.
          Trial registration: HTA project no. 12/27/16; PROSPERO registration no. CRD42013003957.
          Keywords: Art therapy, Mental health disorders, Psychological therapy, Systematic review, Health technology
          assessment, Cost-effectiveness
         * Correspondence: l.uttley@sheffield.ac.uk
         School of Health and Related Research (ScHARR), University of Sheffield,
         Regent Court, 30 Regent Street, Sheffield S1 4DA, UK
                            ©2015 Uttley et al. This is an Open Access article distributed under the terms of the Creative Commons Attribution License
                            (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium,
                            provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://
                            creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
               Uttley et al. BMC Psychiatry  (2015) 15:151                                                                  Page 2 of 13
               Background                                                   Methods
               Mental ill health is recognised as the largest cause of      Search methods
               disability in the United Kingdom [1]. The UK Depart-         Comprehensive literature searches were used to inform
               ment of Health have prioritised making mental health         the clinical and cost-effectiveness reviews. A search
               services more effective and accessible in response to        strategy was developed to identify reviews, randomised
               evidence that such services are not meeting the needs        controlled trials (RCTs), economic evaluations and all
               of some groups of people [2, 3]. The majority of mental      other study types relating to art therapy. Search terms
               health problems are non-psychotic (e.g., depression,         were restricted to “art therapy” or “art therap$”.Metho-
               anxiety, and phobias). For some people with these con-       dological search filters were applied where appropriate.
               ditions, art therapy may be an acceptable alternative        Noother search limitations were used and all databases
               form of psychological therapy than more standard             were searched from inception to present. Searches were
               forms of treatment, such as talking therapies [4]. For       conducted from May–July 2013.
               example, for those who find it difficult to express them-      Databases searched were: MEDLINE and MEDLINE
               selves in verbal language alone as required by more          in Process & Other Non-Indexed citations; EMBASE;
               standard forms of treatment for mental health prob-          Cochrane Library; Science Citation Index; Social Sciences
               lems, arts therapies can provide an alternative means of     Citation Index; CINAHL: Cumulative Index to Nursing
               expression to help service users understand, make            and Allied Health Literature; PsycINFO; AMED: Allied
               sense of, and cope with their distress. There is some        and Complementary Medicine; and ASSIA: Applied Social
               published evidence to support the claim that art             Sciences Index and Abstracts. All resources were searched
               therapy is effective in treating a variety of symptoms       from inception to present.
               and disorders in patients of different ages [5, 6]. How-
               ever, to date a full systematic review of the clinical       Clinical effectiveness review methods
               and cost-effectiveness of art therapy for non-psychotic      Screening of records, study selection, and data extrac-
               mental disorders had not been undertaken. This pro-          tion were performed by one assessor and checked by a
               ject aimed to systematically review the current clinical     second assessor. All studies identified for inclusion
               and cost-effectiveness evidence for art therapy for          at abstract stage were obtained in full text for more
               people with non-psychotic mental disorders. In ad-           detailed appraisal. Non-English studies were translated
               dition, a de novo cost-effectiveness analysis would be       and included if relevant. Quality assessment of included
               undertaken if the systematic review did not identify         studies was performed independently by two reviewers
               suitable studies.                                            using quality assessment criteria adapted from the
                 Art therapy is a specific branch of treatment under        Cochrane risk of bias, CRD guidance, and CASP check-
               the umbrella term “arts therapies” used by the Health        lists to develop a modified tool to allow comprehensive
               Care Professions Council (HCPC) which includes drama         and relevant quality assessment for the included trials.
               therapy and music therapy. For the purpose of this             The inclusion and exclusion criteria for the clinical ef-
               review these other forms of arts therapies, which do         fectiveness review are documented in Table 1.
               not centre on the creation of a sustainable, physical
               piece of visual art, are excluded. Despite art therapy       Mathematical modelling methods
               being an established and practised form of psycho-           A de novo mathematical model was constructed. Due to
               logical therapy for decades, only more recently have         the nature of the study question it was deemed that a
               researchers in the field of art therapy addressed the need   complex model was not required, and that a simple
               to integrate art therapy into a model of evidence-based      model which could more clearly demonstrate the impact
               practise. Therefore, an abundance of literature exists       of key drivers of the cost effectiveness ratio would be
               consisting of single case studies or theoretical concepts    sufficient. As such, an area under the curve model was
               in art therapy [7]. This study was part of a health technol- developed to estimate the gain in utility with the follow-
               ogy assessment commissioned by the National Institute        ing assumptions in the base case.
               for Health Research, UK and aimed to systematically
               assess:                                                        1. That the maximum treatment effect would be
                                                                                 associated with the time at which treatment ended.
                 a)Whatistheevidencethatarttherapyis                          2. That there would be a linear increase in treatment
                   clinically effective in people with non-psychotic             effect, from zero at baseline to the maximum at the
                   mental health disorders?                                      time at which treatment ended.
                 b)Whatistheevidencethatarttherapyis                          3. That there would be a residual effect of treatment
                   cost-effective in people with non-psychotic                   with a linear decline in benefit until there was zero
                   mental health disorders?                                      benefit at 52 weeks.
                   Uttley et al. BMC Psychiatry  (2015) 15:151                                                                                                       Page 3 of 13
                   Table 1 Inclusion and exclusion criteria for the systematic review                and Cognitive Behavioural Group Training provided lar-
                                     Included                          Excluded                      ger decreases in an outcome measure (the Spielberger
                   Population        Non-psychotic clinical            People with psychosis         Test Anxiety Inventory) [12] the effect had not entirely
                                     samples                           Healthy samples               waned at twelve month follow-up. This may be generalis-
                                     a                                                               able to other forms of successful psychological therapy,
                   Intervention       Group art therapy as might       Other “arts therapies”        and conservatively we elected to assume that all benefit
                                     be delivered in the NHS           including drama; music;
                                                                       and dance                     had dissipated at 52 weeks post treatment, although a lon-
                                                                       Play therapy                  ger period of 104 weeks was used in sensitivity analyses.
                   Comparator        Any including: interventions      None                             The conceptual model used to calculate the utility gain
                                     including an RCT containing                                     across time is shown in graphical form in Fig. 1. In this
                                     art therapy; treatment as                                       figure it is assumed that there is a gain in utility of
                                     usual; waiting list; attention                                  0.0780 at week 8. The area under the curve was then
                                     placebo; or other                                               translated in quality adjusted life years (QALYs) assum-
                                     psychological therapy
                   Outcomes          Primary: treatment                Outcomes focussed on          ing 52.18 weeks per year. The QALY considers both
                                     effectiveness; response as        interpretation of the art     duration and quality of life: a person living 10 years at a
                                     determined by changes in          work itself, not the          utility of 0.5 would accrue 5.0 undiscounted QALYs
                                     mental health rating scales;      participant                   whilst a person living 8 years with a utility of 0.8 would
                                     Secondary: Related clinical                                     accrue 6.4 undiscounted QALYs.
                                     or quality of life outcomes
                   Studies           Randomised controlled trials      Non-randomised
                                                                       controlled studies            Results and discussion
                   a
                    Whilst the full health technology assessment (Uttley et al., in press) included  The total number of published articles yielded from elec-
                   studies of both individual and group art therapy, only studies of group art       tronic database searches after duplicates were removed
                   therapy are included in this paper                                                was 10,073. An additional 197 records were identified
                      4. That given the short assumed duration of benefit,                           from supplementary searches, resulting in a total of
                          discounting of future costs and benefits was not                           10,270 records for screening. Of these, 10,221 records
                          necessary.                                                                 were excluded at title/abstract screening. Figure 2 shows
                                                                                                     the flow of studies identified and included in the review.
                      The rationale for choosing 52 weeks as the base case
                   duration of residual benefit was based on a number of                             Clinical effectiveness results and discussion
                   relevant references. Discussing data in Nicholson and                             Eleven RCTs of group art therapy were included in the
                   Berman [8] and in Lambert and Ogles [9], Cooper wrote                             clinical effectiveness review. Eight of the studies were
                   that ‘findings from the empirical research are fairly clear:                      conducted in adults and three were conducted in chil-
                   clients, on average, do not tend to improve once their                            dren. All trials had small final sample sizes with the
                   therapy is over...., but equally they do not tend to deterior-                    number of participants reported to be included in each
                   ate rapidly’ [10]. More recent data provided in Sportel et                        study ranging between 18 and 111. The total number of
                   al. [11], indicate that where Cognitive Bias Modification                         patients in the included studies is 533.
                                                       0.090
                                                       0.080
                                                       0.070
                                                       0.060
                                                      n
                                                      y gai0.050
                                                      t
                                                      i
                                                      l
                                                      i0.040
                                                      Ut
                                                       0.030
                                                       0.020
                                                       0.010
                                                       0.000
                                                             0            50           100           150           200           250          300
                                                                                        Time from start of treatment (weeks)
                     Fig. 1 An illustration of the conceptual model of utility
              Uttley et al. BMC Psychiatry  (2015) 15:151                                                                 Page 4 of 13
                Fig. 2 A modified PRISMA flow diagram of the studies identified and included in the clinical effectiveness review
                As can be seen from Table 2 eight studies compared         effects depending on what art therapy is compared
              art therapy with an active control group. The compara-       against. Additionally, despite common mental health
              tor groups from the included studies can be seen in          symptoms being investigated across the included RCTs,
              Fig. 3. Two of the studies were versus a psychological       the majority of studies were using different measure-
              therapy (Broome [13] & Thyme [14]) whereas six studies       ment scales to assess these outcomes (see Table 3).
              were attention placebo control groups which mimic the        Therefore as there is insufficient comparable data on
              amount of time and attention the intervention group          outcome measure across studies it is not possible to per-
              receives. Three studies compared art therapy with a          form a formal pooled analysis.
              wait-list control or treatment as usual. The majority of       Potential treatment effect modifiers include the experi-
              studies were conducted in a community/outpatient set-        ence/qualification of the art therapist, characteristics
              ting, but the precise setting location for conducting the    that were not consistently reported. Also, the age of the
              intervention was not reported in four studies (Broome        included patients could be a potential effect modifier as
              [13]; Kim [15]; Monti [16]; Monti [17]) and one study        eight studies are of adults and three are of children. Pre-
              was reported to be conducted in an outpatient setting        existing physical conditions were present in seven of the
              (Lyshak-Stelzer et al. [18]).                                included studies which could also represent a potential
                The symptoms or ‘outcome domains’ under investiga-         treatment effect modifier.
              tion and associated outcome measures are reported in           The direction of statistically significant results from
              Table 3.                                                     the 15 included RCTs are summarised in Table 4.
                The study populations were heterogeneous in their            As can be seen in Table 4, in 10 of the 11 included
              clinical profiles highlighting the wide application of art   studies there were improvements from baseline in some
              therapy but also demonstrating the difficulty in obtain-     outcomes in the art therapy groups. However, both the
              ing a pooled estimate of treatment effect. The control       intervention and the control groups improved from
              groups across the included studies are heterogeneous         baseline in three studies with no significant difference
              therefore there may be different estimates of treatment      between the groups (Broome [13]; McCaffrey [19] and
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...Uttley et al bmc psychiatry doi s research article open access the clinical and cost effectiveness of group art therapy for people with non psychotic mental health disorders a systematic review analysis lesley matt stevenson alison scope andrew rawdin anthea sutton abstract background majority problems are e g depression anxiety phobias some may be more acceptable alternative form psychological than standard forms treatment such as talking therapies this study was part technology assessment commissioned by national institute uk aimed to systematically appraise effective evidence methods comprehensive literature searches studies examining in populations were performed quantitative evaluating conducted results eleven randomised controlled trials included patients meta not possible due heterogeneity insufficient comparable data on outcome measures across control groups varied between but no wait list attention placebo controls comparators associated significant positive changes relative s...

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